Research organizations are in the core business of discovering new knowledge and developing existing knowledge. Knowledge sharing ensures value creation of the knowledge asset and ensures research organizations maintain their competitive advantage. Knowledge sharing occurs through creation of social networks that create an environment that allows for sharing of knowledge between individual and social units. Organizations adopt information and communication technology in order to provide an avenue that allows for social networking regardless of time and distance. The purpose of the study was to analyze the influence of information and communication technology on knowledge sharing with interest on the ICT elements of tools, infrastructure, competencies and infrastructure. The target population of 172 employees working for the Centers for Disease Control and Prevention in Kenya provided the primary data that was collected through questionnaires. Multiple regression analysis, descriptive statistics and correlation analysis were used to examine the data. Results indicate that ICT infrastructure and ICT structure was significant in explain knowledge sharing in research organizations. The study however had limitations, in that it did not look at other organizational factors besides ICT that influence knowledge sharing like people and processes. The research was carried out over a period of seven months from November 2017 and May 2018.