Includes bibliographical references and index.

Machine generated contents note: List of ContributorsPrefacePart 1: Introduction1 Concept & Scope of Modern VaccinesNadeem Sheikh PhD, Huw Davies PhD, Clint Schmidt PhDPart 2: Principles of Vaccine Design2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine AdjuvantsHeather L. Wilson PhD, Scott Napper PhD, George K. Mutwiri, Sylvia van Drunen-Little van den Hurk, Hugh Townsend PhD VIDO, Lorne A. Babiuk PhD, Andrew A. Potter PhD, Volker Gerdts PhD3 Antigen Processing and Presentation by MHC Class I, II and Non-Classical MoleculesAnthony N. Antoniou PhD, Izabela Lenart, David B. Guiliano, Simon J. Powis PhD4 Understanding the Mucosal Immune System for Better Mucosal VaccineJanine Bilsborough PhD, Joanne L. Viney PhD5 Immunological Memory: T Cells in HumansMaria Candela Iglesias, Victor Appay PhD, Arnaud Moris,6 Immunological Memory: B CellsFrances Eun-Hyung Lee MD, I�naki Sanz MD7 Utility of Mouse Models in Vaccine Design and DevelopmentCatherine M. Bosio PhD, Megan McLeod PhD, Philippa Marrack PhD, Ross M. Kedl8 Utility of Non-Human Primate Models for VaccinePreston A. Marx PhD, Alexander F. VoevodinPart 3: Antigen Discovery (Macro approach vs. Epitope focused)9 Sequence Based Computational Approaches to Vaccine Discovery and DesignDarrick Carter PhD10 High-Throughput Proteomics (Microarrays only)Huw Davies PhD11 Phage LibrariesAaron K. Sato PhDPart 4: Antigen Engineering12 Attenuated Microbial VaccinesRichard W. Titball BSc, FRCPath, Helen S. Atkins BSc, PhD13 Virus-Like Particles as Antigen ScaffoldsBryce Chackerian PhD, John T. Schiller PhD14 Recombinant MVA Vaccines, Optimisation, Pre-clinical and Product DevelopmentYper Hall BSc, Miles Carroll PhD15 Recombinant Adenoviruses for VaccinationNelson Cesar Di Paolo PhD, Dmitry Shayakhmetov PhD, Andre; Lieber MD, PhD16 Recombinant AvipoxvirusesMichael A. Skinner PhD, Stephen M. Laidlaw17 Intracellular Facultative Bacterial Vectors For Cancer ImmunotherapyPatrick Guirnalda , Laurence Wood, Matthew Seavy, Yvonne Paterson PhD18 Nucleic Acid VaccinationBritta Wahren, Margaret A. Liu MD19 Artificial Antigen-presenting Cells: Large Multivalent ImmunogensMatthew F. Mescher PhD, Julie M. CurtsingerPart 5: Delivery Systems20 Transcutaneous Immunization via Vaccine Patch Delivery SystemRobert C. Seid PhD, Gregory M. Glenn MD21 Needle-free Jet Injection for Vaccine AdministrationBrian R. Sloat, Hoi K. Tran, Zhengrong Cui PhD22 Oral Vaccines: an old need and some new possibilitiesAmit A. Lugade PhD, Kalathil Suresh PhD, Yasmin Thanavala PhD23 Adjuvants: From Serendipity to Rational DiscoveryDerek T. O'Hagan PhD, Andreas Wack PhD24 Immunostimulatory Properties of Biodegradable MicroparticlesF.A. Sharp, E.C. Lavelle25 Co-administration of Costimulatory MoietiesCarolina Arancibia, Yvette Latchman PhD26 Toll Receptors in Relation to Adjuvant EffectsDipshikha Chakravortty PhD, Amit Lahiri PhD, Priyanka Das PhDPart 6: Regulatory Considerations27 Regulatory Issues (FDA & EMEA)Murrium Ahmad PhD, Victoria Byers, Peter WilsonPart 7: Evaluating Vaccine Efficacy28 Immune Monitoring Design within the Development Pipeline for an Immunotherapeutic or Preventive VaccineSylvia Janetzki PhD, Pedro Romero MD, Mario Roederer PhD, Diane L. Bolton PhD, Camilla Jandus29 Clinical Development Strategy: Nuts and BoltsCandida Fratazzi MD, Claudio Carini MD, PhD30 Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient StratificationRobert C Rees PhD, Stephanie Laversin, Cliff Murray PhD, Graham Ball PhDPart 8: Implementing Immunizations/Therapies31 Mass Immunization StrategiesDavid L. Heymann MD, DTM&H, Bruce R. Aylward, Rudolf H. Tangermann32 The Role of Mathematical Models in Vaccine Development and Public Health Decision MakingMarie-Claude Boily PhD, Marc Brisson PhD, Benoit M�asse PhD, Sir Roy M Anderson FRS, FMedSci33 Vaccine SafetyJohn Iskander MD, MPH, Claudia Vellozzi MD, MPH, Jane Gidudu MD, MPH, Robert T. Chen MD, MA.

"This book addresses a profound deficiency in the field of vaccine research and development, namely the lack of a single volume describing the design and construction of vaccine strategies from first principles to implementation. This is an authoritative textbook that details a comprehensive and systematic approach to the science of vaccinology focusing on not only basic science, but the many stages required to commercialize and navigate the regulatory requirements for human application both in the United States and Europe. The book has broad appeal to clinicians, scientific and medical researchers alike, and graduate students"--Provided by publisher.

Electronic reproduction. Palo Alto, Calif. : ebrary, 2011. Available via World Wide Web. Access may be limited to ebrary affiliated libraries.