With organizations faced by diverse challenges that impede their competitiveness, focus has over time been on competitiveness and productivity. Remote working has also been adopted to allow employees work from home. In such arrangement, workforce welfare is neglected and various health problems are reported, causing less employee engagement, morale, and dissatisfaction and suboptimal outputs. Consequently, even the adoption of technology turns out counterproductive in firms. This study sought to determine the effect of remote working on employee wellness by analyzing employees in non-governmental organizations in Nairobi City County, Kenya. The study's specific objectives were to determine the effect of job-related factors, organizational factors, and work-life balance on employee wellness. The study followed a positivist research paradigm and applied a cross-sectional descriptive research design to quantitatively describe the relationships between the study variables. From the total population of 80,229 employees in the registered non-governmental organizations in Kenya, a sample of 398 was targeted. To achieve adequate response rate, the study targeted 7 respondents, which is 1 senior-level, 3 mid-level and 3 junior-level employees from each of the 60 international and national non-governmental organizations based in Nairobi County. Therefore, stratified random sampling was employed for an even representation of the 60 organizations. A convenient sampling technique was applied to choose participants based on availability. A pilot study targeting 40 employees from 6 organizations in Kiambu County was conducted. The firms used for pilot testing were not considered during the actual research. Adequate research quality concerning validity and reliability was achieved through Cronbach’s alpha. Data was analysed through SPSS. Regression analysis results indicated a weak relationship between the independent variables: job-related factors, organizational factors and work-life balance and the employee wellness. Based on coefficients, both Job-related and organizational factors were significant at 0.05 significant level. Similarly, work-life balance had a positive, statistically significant influence on employee wellness. The study concludes that job-related factors, organizational factors, and work-life balance have a weak joint effect on employee wellness. Work-life balance has a positive, statistically significant correlation with employee wellness while job-related and organizational factors have significant influence on employee wellness. Organizations should enhance job-related and organizational factors to enhance employee work-life balance which in turn improves employee wellness. Further research can be implemented to test the mediational role of work-life balance in the relationship between job-related and organizational factors and employee wellness.